methotrexate (brand names: Rheumatrex, Trexall)-A

A drug that is capable of blocking the metabolism of cells (an antimetabolite). As a result of this effect, methotrexate has been found to be helpful in treating certain diseases associated with abnormally rapid cell growth, such as cancer of the breast and psoriasis. Recently, methotrexate has been shown to be effective in inducing miscarriage (for example, in patients with ectopic pregnancy). This effect of methotrexate is attributed to its action of killing the rapidly growing cells of the placenta. Methotrexate has also been found to be very helpful in treating rheumatoid arthritis, although its mechanism of action in this illness is not known. Methotrexate seems to work, in part, by altering aspects of immune function that may play a role in causing rheumatoid arthritis. Generic is available.